An immunological study of vitiligo

Abstract

Estimation of peripheral T lymphocytes T3, T4, T8 and NK cells was carried out in 30 cases of different clinical types of vitiligo by direct immunofluorescence technique. The cases were divided into two broad groups (1) Localised; and (2) Generalised. These cases were again divided into 3 groups as per duration of disease. Thirty healthy subjects served as control. Decrease in T3 and T4 and increase in T8 with decrease of T4/T8 ratio was seen in both localised and generalised variety. But the T4/T8 ratio was decreased to a greater extent in generalised variety. The NK cells showed significant increase in the generalised variety. As per disease T4/T8 ratio was reduced maximally in patients with disease duration less than one year. Of the generalised category NK cells were increased more in patients having disease duration more than 1 year.