Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Letter to the Editor
2014:80:5;458-459
doi: 10.4103/0378-6323.140312
PMID: 25201851

Bilateral madarosis due to papular mucinosis

Vani Vasanth1 , Chandrashekar Byalakere Shivanna1 , Venkataram Mysore2
1 Department of Dermatology, Cutis Academy of Cutaneous Sciences, Bangalore, Karnataka, India
2 Department of Dermatology, Venkat Charmalaya, Institute for Advanced Dermatology and Postgraduate Training, Bangalore, Karnataka, India

Correspondence Address:
Vani Vasanth
19, 'Skanda', Rajahamsa Road, Ittamadu, BSK 3rd Stage, Bangalore - 560 085, Karnataka
India
How to cite this article:
Vasanth V, Shivanna CB, Mysore V. Bilateral madarosis due to papular mucinosis . Indian J Dermatol Venereol Leprol 2014;80:458-459
Copyright: (C)2014 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

Madarosis is a window to diagnosis for several diseases. Usually, the patient with madarosis consults a dermatologist for cosmetic reasons. Thorough investigation is warranted to arrive at an accurate diagnosis of the underlying condition. We report a patient with papular mucinosis who presented to us with bilateral madarosis as the only complaint.

A 46-year-old woman reported with the chief complaint of loss of eyebrows. She had first noticed diffuse thinning of her eyebrows about 10 years ago that had gradually progressed to complete loss. There was no history of itching, redness, or eruptions at the site. There was no history of patchy loss of eyebrows or loss of hair from any other body area. She had no systemic complaints and sought consultation for cosmetic reasons.

On examination, there was diffuse loss of hair from the eyebrows with no associated erythema [Figure - 1]a. Facial skin was thickened and hard to pinch. Tiny, yellowish to skin-colored papules were scattered all over the face; these were more closely set on the forehead [Figure - 1]b. The helices were involved bilaterally, whereas the neck was spared. The patient had not noticed these skin lesions earlier. There were no similar lesions elsewhere on the body. There was no thickening of skin over the shins and the patient was not overweight.

Figure 1: (a) Diffuse loss of bilateral eyebrows with thickening of facial skin (b) Multiple yellowish to skin colored papules with thickening of skin seen over the forehead (c) Re-growth of eyebrow hair following three months of treatment (d) Resolution of papules following three months of treatment

A provisional diagnosis of localized mucinosis was made. Complete blood counts, peripheral smear, liver function test, thyroid function test, fasting lipid profile, fasting and post-prandial blood glucose were all within normal limits.

Histopathology showed epidermal hyperkeratosis and follicular plugging. The papillary and upper reticular dermis showed deposits of homogenous pinkish material. There was a perifollicular lymphocytic infiltrate [Figure - 2]a. PAS and Congo Red stains were negative, while Alcian blue staining was positive [Figure - 2]b and revealed mucin deposition in the upper and mid dermis confirming the diagnosis of localized papular mucinosis.

The patient was treated with oral isotretinoin 20 mg/day along with topical retinoic acid and a sunscreen. Following this, she showed good improvement with regrowth of eyebrow hair in about three months along with disappearance of the waxy papules and regression of facial thickening[Figure - 1]c and d. Later, the patient was non-compliant with medication because of which there was a recurrence of eyebrow loss though there was no thickening of skin or papules. She has been re-started on oral isotretinoin.

Figure 2: (a) H and E, stain showing pinkish mucin deposits in the upper and mid-dermis with clefts (b) Alcian blue staining showing mucin deposits in the upper and mid-dermis

The term madarosis is derived from the Greek word " madaros" meaning "pulpy or bald." Ciliary madarosis refers to loss of eyelashes while superciliary madarosis refers to loss of eyebrows. Madarosis can be either scarring or non-scarring. Some of the common causes of madarosis include infections like staphylococccal blepharitis and leprosy, endocrine disorders like hypothyroidism, drugs, auto-immune conditions like alopecia areata and trauma. [1]

Papular mucinosis is an idiopathic, cutaneous condition. The term papular mucinosis has been used synonymously with lichen myxedematosus and scleromyxedema, but as a general rule, scleromyxedema refers to a generalized distribution of lesions. [2] Papular mucinosis affects both sexes equally and commonly occurs beyond 30 years of age. It manifests with asymptomatic waxy, flat-topped, confluent, skin-colored papules. The commonest sites involved in localized papular mucinosis are the acral areas: dorsal aspect of hands, feet, elbows and face, ears, and neck.

Serum electrophoresis may show an abnormal paraprotein of IgG type. Histology shows mucin deposition in between collagen bundles in the upper dermis. There is dermal fibrosis with increase in the number of fibroblasts. The mucinous material is glycosaminoglycan which stains with Alcian blue.

Treatment of this condition remains unsatisfactory. Melphalan is the drug of choice for generalized scleromyxedema. Localized lichen myxedematosus has been treated with tacrolimus ointment. Systemic steroids alone may be ineffective. [3] Both isotretinoin [4] and etretinate have been associated with improvement. Other options include cyclophosphamide alone or in combination with prednisone, interferon-alpha, cyclosporine, PUVA photochemotherapy, electron- beam therapy, and IVIg. [5]

The management of madarosis requires identification and treatment of the underlying condition. Though rare, papular mucinosis should be considered in the differential diagnosis of madarosis. It causes non-scarring type of madarosis and as seen in our case, hair regrowth does occur with treatment of the disease.

References
1.
Sachdeva S, Prasher P. Madarosis: A dermatological marker. Indian J Dermatol Venereol Leprol 2008;74: 74-6.
[Google Scholar]
2.
Rongioletti F, Rebora A. Updated classification of papularmucinosis, lichen myxedematosus, and scleromyxedema. J Am Acad Dermatol 2001;44:273-81.
[Google Scholar]
3.
Sarkany RP, Breathnach SM, Morris AA. Metabolic and nutritional disorders. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook's Textbook of Dermatology, 8 th ed. Oxford: Wiley-Blackwell; 2010. p. 59.21-3.
th ed. Oxford: Wiley-Blackwell; 2010. p. 59.21-3.'>[Google Scholar]
4.
Hisler BM, Savoy LB, Hashimoto K. Improvement of scleromyxedema associated with Isotretinoin therapy. J Am Acad Dermatol 1991;24:854-7.
[Google Scholar]
5.
Rothfleisch JE. Papularmucinosis. Dermatol Online J 2001;7:13.
[Google Scholar]

Fulltext Views
2,860

PDF downloads
1,399
Show Sections