Generic selectors
Exact matches only
Search in title
Search in content
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Special Article
Specialty Interface
Studies
Study Letter
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Tables
Technology
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF
Letter to the Editor
2010:76:6;701-701
doi: 10.4103/0378-6323.72444
PMID: 21079319

Cosmeceutical testing: Ethical and scientific issues

Gurcharan Singh1 , Bhanu Prakash2
1 Department of Dermatology and STD, Sri Devaraj Urs Medical College, Tamaka, Kolar, India
2 Department of Dermatology and STD, Vydehi Hospital, VIMS & RC, Bangalore, India

Correspondence Address:
Gurcharan Singh
108, A, Jal Vayu Vihar, Kamanahalli, Bangalore - 560 043
India
How to cite this article:
Singh G, Prakash B. Cosmeceutical testing: Ethical and scientific issues. Indian J Dermatol Venereol Leprol 2010;76:701
Copyright: (C)2010 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

We read with interest the article "The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women" by Jerajani et al., published in a recent issue of IJDVL. [1] Ideally, a cosmeceutical should be clinically tested for efficacy to ensure proven skin benefit and also to substantiate marketing claims. [2] The authors′ endeavor in this respect is sincerely appreciated. However, few irregularities observed in this study need consideration.

We are given to understand that the principal investigator belongs to a faculty of medical college and the study has been done at a totally different center. Is it ethical for us to use both our credentials (as a consultant and as a faculty) as and in the way we need it. Would it not enhance the credibility of the study if the study was done in an academic institution rather than a private center?

Apart from the principal investigator who is a clinician, all the authors are from the cosmeceutical company. Considering that the product tested was from the same company is it not necessary that the authors should have mentioned any conflict of interest in their study. A double blinding would have mitigated this issue to some extent. A company′s product, when tested for the efficacy, generally requires some remuneration/assistance to be given to the investigator, patients, and the institution where it is being done. Considering that, the author′s claim of nil source of support in the study requires clarity.

All patients with epidermal pigmentation were included in the study, but various types of epidermal pigmentations, viz., melasma, post inflammatory, post acne, freckles, etc. have not been mentioned and efficacy of the formulation has not been correlated with the same.

Presuming that it is a vehicle controlled study, the composition of control lotion and the sunscreen in the test lotion is not available in the text. What is the explanation for darkening of the skin observed in the control group? Cosmeceuticals that contain topically applied vitamins have an increasing role in the skin care. [3] Since the efficacy is tested on the final formulation which, apart from vitamins, contains an unspecified sunscreen as well, it is difficult to separate efficacy of any individual active ingredient.

Therefore, even though the investigators have conducted a study using sophisticated bioengineering tools for assessment, the aforesaid scientific and ethical issues need to be addressed.

References
1.
Jerajani HR, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ. The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: A randomized, double-blind trial. Indian J Dermatol Venereol Leprol 2010;76:20-6.
[Google Scholar]
2.
Draelos ZD. Cosmeceuticals: undefined, unclassified, and unregulated. Clin Dermatol 2009;27:431-4.
[Google Scholar]
3.
Manela-Azulay M, Bagatin E. Cosmeceuticals vitamins. Clin Dermatol 2009;27:469-74.
[Google Scholar]

Fulltext Views
166

PDF downloads
114
Show Sections