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Studies
In vitro susceptibility of dermatophytes to itraconazole
V Pankajalakshmi Venugopal, Taralakshmi Venugopal
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Correspondence Address:
V Pankajalakshmi Venugopal
Correspondence Address:
V Pankajalakshmi Venugopal
| How to cite this article: Venugopal V P, Venugopal T. In vitro susceptibility of dermatophytes to itraconazole. Indian J Dermatol Venereol Leprol 1992;58:368-371 |
Copyright: (C)1992 Indian Journal of Dermatology, Venereology, and Leprology
Abstract
The in vitro activity of itraconazole was investigated against 88 clinical isolates of dermatophytes. The isolates included Microsporum canis-50, M. audovinii-5, Trichophyton rubrum-6, T. mentagraphytes-5 T.violaceum-12, T.simii-5, T verrucosum-1, T.soundanense-1, T. erinacei-1 and Epidermophyton flooccosum-2 isolates. The results were compared with that of ketoconazole and griseofulvin.Itraconazole was more active, inhibiting 85 of the 88 isolates at a concentration of 0.5 µg/ml (MIC range 0.01-1 µg/ml). Ketoconazole (MIC range 0.1-10 µg/ml) required 2.5 µg/ml and 5 µg/ml of the drug respectively for inhibition of all the isolates except one of Microsporum species.
Keywords: Dermatophytes, Itraconazole
