Named cells in dermatology

Fiona F Sequeira¹ , Suneil Gandhi² , Usha Kini³ , Ishwar Bhat¹

¹ Department of Dermatology, St John's Medical College and Hospital, Bangalore, Karnataka, India
² Department of Dermatology, JN Medical College, Belgaum, India
³ Department of Pathology, St John's Medical College and Hospital, Bangalore, Karnataka, India

Correspondence Address:
Fiona F Sequeira
Department of Dermatology, St John's Medical College and Hospital, Koramangala, Bangalore, Karnataka - 560 034
India

Introduction

This article briefly describes the named cells in dermatology. It′s purpose is to serve as a ready reckoner to the postgraduates during their quiz preparations. They include the following:

1. General category
   1. Normal cutaneous anatomy: Langerhans cells, Glomus cells, Veil cells, Mast cells
   2. Bullous disorders: Tzanck cells
   3. Eczematous disorders: Tadpole cells
   4. Metabolic and storage disorders: Gargoyle cells, Gaucher′s cell, Xanthoma cells
   5. Tumors: Basalioma cells, Basophilic and shadow cells, Doughnut cells, Flower cells, Granular cells, Halo cells, Hibernoma cells, Paget cells, Sezary cells, Signet ring cells, Spider web cells, Strap cells, Reed Sternberg cells, Vulvar Clear Cells of Toker, Floret giant cells
   6. Histiocytic disorders: Touton giant cells
   7. Collagen vascular disorders: LE cells, Tart cells
   8. Drug induced: Podophyllin cells
   9. Keratinization disorders: Mantle cells, Half and half cells
   10. Disorders of the panniculus: Bean bag cells
   11. Disorders of photoimmunology: Sunburn cells
   12. Benign pigmented lesions: Balloon cells
   13. Papulosquamous disorders: Pekin cells
2. Infectious disorders
   1. Bacterial: Clue cells, Downey cells, Greenblatt and Pund cells, Lepra cells, Mikulicz cells, Von Hansemann cells, Langhan giant cells
   2. Protozoal: Wright cells
   3. Viral: Koilocytes, Warthin Finkeldey cells, Mitosoid cells

[Table 1].

[SUPPORTING:1]

[Figure - 1], [Figure - 2], [Figure - 3], [Figure - 4], [Figure - 5] and [Figure - 6].

Figure 1: Hibernoma. Large polyhedral fat cells containing eosinophilic granular cytoplasm (×200)

Figure 2: Signet ring cells in an adenocarcinoma. Sheet of large cells with vacuolated cytoplasm pushing the single hyperchromatic nucleus to the periphery (×400)

Figure 3: Reed Sternberg cells in a case of Hodgkin's lymphoma. Note the bilobed nucleus with a resemblance to an "owl's eye" with prominent eosinophilic inclusion-like nucleoli (×200)

Figure 4: LE cells. Distorted nuclear material in the cytoplasm of a polymorphonuclear leukocyte causing the nucleus to be compressed and pushed to the periphery (×1000)

Figure 5: Clue cells. Squamous epithelial cells with a large number of coccobacillary organisms, Gardnerella vaginalis and other anaerobic bacteria densely attached in clusters to their surfaces give them a granular appearance (×400)

Figure 6: Lepra cells. Large cells with their abundant cytoplasm, occupying the greater part of the cell and filled with mycobacteria leprae bacilli, highlighted by modified Fite Faraco (MFF stain, x1000)

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