Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Letter to the Editor - Case Letter
2020:86:5;549-551
doi: 10.4103/ijdvl.IJDVL_807_19
PMID: 32719199

Periungual tumor on the finger

Xiang-Xi Wang, Jin Yu
 Department of Dermatology and Venerology, Peking University First Hospital; Research Center for Medical Mycology, Peking University; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Peking University First Hospital; National Clinical Research Center for Skin and Immune Diseases, Beijing, China

Correspondence Address:
Jin Yu
Department of Dermatology and Venerology, Peking University First Hospital, 1st Xi'an Men Street, Xicheng District, Beijing
China
Published: 28-Jul-2020
How to cite this article:
Wang XX, Yu J. Periungual tumor on the finger. Indian J Dermatol Venereol Leprol 2020;86:549-551
Copyright: (C)2020 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

An apparently healthy 73-year-old man presented with a slow-growing mass, 1.0-cm in diameter, affecting the periungual region of his left middle finger, with ulceration and rolled out edges for three years. The lesion gradually invaded his nail to cause nail-bed hyperkeratosis [Figure - 1]. Lesional histopathology revealed nodules of basaloid cells (small cells having minimal cytoplasm with uniform round or oval darkly staining nuclei) interspersed with palisading and stromal retraction; predominantly affecting the upper dermis with epidermal intrusion [Figure - 2]a and b]. Tumor cells stained negative for epithelial membrane antigen [Figure - 2]c and Sox2, and positive for Ber-EP4 [Figure - 2]d, thus confirming the diagnosis of basal cell carcinoma. We performed Mohs micrographic surgery [Figure - 3]a. No recurrence has been noted at one-year follow-up [Figure - 3]b.

Figure 1: A 1.0 cm mass in the periungual region of the middle finger, with ulceration and rolled out edges and hyperkeratosis of the nail bed

Basal cell carcinoma is the commonest skin neoplasm, but the least common nail tumor.[1] It predominantly affects the head and neck region,[2] nail unit involvement being extremely rare with only 31 reports in the English literature.[1],[2],[3] Fingers are involved more than toes, thumb being the commonest digit.[1]

Basal cell carcinoma is primarily caused by ultraviolet radiation, however, the rarity of nail unit basal cell carcinoma despite digits being relatively well sun-exposed remains unexplained.[1],[3] The paucity of pilosebaceous units in this region might be a possible reason.[4] Some factors implicated for the etiopathogenesis of nail unit basal cell carcinoma include trauma, carcinogens (azo dyes and arsenic) and chronic radiation exposure.[1]

The clinical presentation of nail unit basal cell carcinoma is variable, resembling several inflammatory or infectious diseases of the nail including chronic paronychia, dermatophytosis, bacterial infections, herpes simplex, chronic eczema and trauma. Differential diagnoses also include other benign or malignant neoplasms like pyogenic granuloma, squamous cell carcinoma, Bowen's disease, glomus tumor and longitudinal melanonychia or melanoma.[3],[5] It can also be misdiagnosed as a habit tic.[6] Characteristic dermoscopic features of basal cell carcinoma help us to rule out other clinical mimickers, however, histopathological examination is essential for diagnosis.[3]

Various therapeutic modalities exist for this condition like topical imiquimod, topical 5-fluorouracil, intralesional interferon, radiation therapy, electrodessication and curettage, cryosurgery, laser, standard excision and Mohs micrographic surgery.[2] Surgical excision is the treatment of choice due to lowest rate of recurrence.[2] Compared to standard surgical excision, Mohs micrographic surgery ensures better tissue conservation and marginal clearance, thus resulting in maximum preservation of digital function.[1] As a result, Mohs micrographic surgery is currently the most favoured treatment option for nail unit basal cell carcinoma where tissue conservation is important. Forman et al. concluded that 8 of the initial 22 reported cases of nail unit basal cell carcinoma were successfully treated with Mohs micrographic surgery.[5] Five cases healed by second intention while three cases required full-thickness skin grafts.[5] Until now, Mohs micrographic surgery has been performed for 14 nail unit basal cell carcinomas in English literature, including our case. In conclusion, Mohs micrographic surgery is a satisfactory treatment option for nail unit epithelial neoplasms, including basal cell carcinoma.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given his consent for his images and other clinical information to be reported in the journal. The patient understands that his name and initials will not be published and due efforts will be made to conceal the identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References
1.
Shimizu I, Cohen PR, Macfarlane DF. Surgical treatment of basal cell carcinoma of the nail unit. Int J Dermatol 2013;52:996-8.
[Google Scholar]
2.
Pollo T, Rabay FM, de Lima EM, Gonçalves FD, Mandelbaum SH. Subungual basal cell carcinoma: A rare nail tumor with a challenging diagnosis. Skin Appendage Disord 2019;5:251-3.
[Google Scholar]
3.
Tavares LL, Costa JC, Delcourt NC, Rodrigues NC. Periungual basal cell carcinoma. An Bras Dermatol 2018;93:114-5.
[Google Scholar]
4.
Bandyopadhyay D, Sen S. Periungual Basal cell carcinoma: A case report with review of literature. Indian J Dermatol 2011;56:220-2.
[Google Scholar]
5.
Forman SB, Ferringer TC, Garrett AB. Basal cell carcinoma of the nail unit. J Am Acad Dermatol 2007;56:811-4.
[Google Scholar]
6.
Shah D, Leopold G, Sowden J. Basal cell carcinoma masquerading as habit tic. Clin Exp Dermatol 2011;36:920.
[Google Scholar]

Fulltext Views
3,286

PDF downloads
1,755
Show Sections