Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Letter to the Editor
2011:77:2;193-194
doi: 10.4103/0378-6323.77464
PMID: 21393953

Prevalence of metabolic syndrome in patients with psoriasis

Safiye Kutlu1 , Tugba Rezan Ekmekci1 , Sema Ucak2 , Adem Koslu1 , Yuksel Altuntas2
1 Department of Dermatology, Sisli Etfal Research and Training Hospital, Istanbul, Turkey
2 Department of Endocrinology, Sisli Etfal Research and Training Hospital, Istanbul, Turkey

Correspondence Address:
Tugba Rezan Ekmekci
Ihlamurdere Cad. No:153/19 Besiktas, Istanbul
Turkey
How to cite this article:
Kutlu S, Ekmekci TR, Ucak S, Koslu A, Altuntas Y. Prevalence of metabolic syndrome in patients with psoriasis. Indian J Dermatol Venereol Leprol 2011;77:193-194
Copyright: (C)2011 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

Associations between psoriasis and metabolic diseases, such as obesity, diabetes, dyslipidaemia, and cardiovascular disease have been recognized. Metabolic syndrome (MetS) is a cluster of risk factors, including central obesity, atherogenic dyslipidaemia, hypertension, and glucose intolerance. [1]

Combining the age of onset with the HLA pattern, psoriasis can be identified two subtypes. Type I (early onset) has an onset <40 years of age, and HLA-Cw6, -B13, -Bw57, and -DR7 are over-represented; inheritance is familial. Type II (late onset) has an onset >40 years of age, and the HLA associations are weaker; there is no familial risk and the likelihood of joint and nail involvement is greater. The most common association is HLA-Cw6. [2]

The aim of this study was to investigate the prevalence of MetS in patients with psoriasis.

Two hundred fifty psoriatic patients admitted to the dermatology clinic during 2007−2009 were included. Patients receiving any systemic treatment for psoriasis, patients in whom the duration of psoriasis was <6 months, patients <18 years of age were excluded from the study. Psoriasis was diagnosed based on clinical and/or histopathologic criteria. The data collected included age, gender, waist circumference, blood pressure, duration of psoriasis, age of onset of psoriasis, and severity of psoriasis. Psoriasis was classified as type I and II. Measurement of psoriasis severity was performed using the psoriasis area and severity index (PASI).

MetS was diagnosed based on waist circumference and two or more criteria of the International Diabetes Federation (IDF), as follows: waist circumference >94 cm in males or >80 cm in females; triglycerides ≥150 mg/dl; high-density lipoprotein cholesterol <40 mg/dl in males or <50 mg/dl in females; blood pressure ≥130/85 mmHg (or the use of antihypertensive drugs); and fasting plasma glucose ≥100 mg/dl (or previously diagnosed type 2 diabetes).

Venous samples were obtained at the enrollment visit after the subjects had fasted overnight. Serum lipids and blood glucose were measured using the end-point colorimetric method.

The study was approved by the ethics committee of Sisli Etfal Research and Training Hospital. Data analysis was performed using SPSS 11.5(SPSS Inc., Chicago, IL, USA). The results are expressed as the mean ± SD. Differences were considered statistically significant at a P-value <0.05. Student′s t-test, Mann−Whitney U-test, chi-square test, and Fisher′s exact test were performed.

The study included 250 psoriatic patients (131 females, 119 males; age range: 18−85; mean age: 41.39 ± 14.7). In psoriatic patients, the PASI score ranged from 0.3 to 36.6 (median: 7.93 ± 6.87). Fifty-nine patients (23.6%) had a PASI score >10. Type I psoriasis (188 patients, 75.2%) was more common than type II psoriasis (62 patients, 24.8%).

Seventy-seven psoriatic patients (30.8%) had MetS. When comparing psoriatic patients with MetS to psoriatic patients without MetS, there was no statistically significant difference in the two groups with respect to the severity of psoriasis. Type 2 psoriasis was more common in psoriatic patients with MetS. In addition, although there was statistically significant difference in the two groups with respect to age, as late onset psoriasis was more common in the first group and early onset psoriasis was more common in the second group, there was no statistically significant difference between the two groups with respect to the duration of psoriasis [Table - 1].

Table 1: Comparing psoriatic patients without MetS to with MetS to all patients with both psoriasis and MetS in both study groups with respect to the demographic features and the characteristics of psoriasis

The prevalence of MetS varies among populations because of differences in genetic background, diet, levels of physical activity, levels of over- and under-nutrition, and body habits. [1] In one study using IDF, the prevalence of MetS in Turkey was 34.6%. [3] We found that the prevalence of MetS in psoriatic patients was 30.8%.

The relationship between MetS and the severity of psoriasis is controversial. Sommer et al.,[4] reported an increased prevalence of MetS in patients with moderate-to-severe psoriasis. In contrast, Gisondi et al., [1] and Takahashi et al., [5] detected no correlation between the severity of psoriasis and MetS. Again, it was demonstrated that the duration and severity of psoriasis had no effect on insulin resistance. [6] We did not find a link between the duration of psoriasis and MetS or the severity of psoriasis and MetS.

Gisondi et al., [1] observed that patients with MetS had an earlier age of onset of psoriasis and a longer disease of duration. Conversely, in our study the link between late onset psoriasis and MetS was detected. Again, Ucak et al.,[6] also observed that impaired glucose tolerance was more common in type II psoriatic patients. Moreover, Takahashi et al., [5] found a positive correlation between the severity of psoriasis and obesity and diabetes. Although we cannot determine whether or not psoriasis or MetS comes first by our patients′ histories, the absence of the association between the severity and the duration of psoriasis and MetS and the close relationship between type II psoriasis and MetS led us to reason that obesity itself could predispose an individual to developing psoriasis, as previously suggested. [5]

References
1.
Gisondi P, Tessari G, Conti A, Piaserico S, Schianchi S, Peserico A, et al. Prevalence of MetS in patients with psoriasis: A hospital-based case-control study. Br J Dermatol 2007;157:68-73.
[Google Scholar]
2.
Christophers E, Mrowietz U. Psoriasis. In: Burgdorf WHC, Plewig G, Wolff HH, Landthaler M, editors. Dermatology. 3 rd ed. Heidelberg: Springer Medizine Verlag; 2009. p. 507.
[Google Scholar]
3.
Gündogan K, Bayram F, Capak M, Tanriverdi F, Karaman A, Ozturk A, et al. Prevalence of MetS in the Mediterranian region of Turkey: Evaluation of hypertension, diabetes mellitus, obesity, and dyslipidemia. Metab Syndr Relat Disord 2009;7:427-34.
[Google Scholar]
4.
Sommer DM, Jenisch S, Suchan M, Christophers E, Weichenthal M. Increased prevalence of the MetS in patients with moderate to severe psoriasis. Arch Dermatol Res 2006;298:321-8.
[Google Scholar]
5.
Takahashi H, Tsuji H, Takahashi I, Hashimoto Y, Ishida-Yamamoto A, Lizuka H. Prevalence of obesity/adiposity in Japanese psoriasis patients: Adiposity is correlated with the severity of psoriasis. J Dermatol Sci 2009;55:74-6.
[Google Scholar]
6.
Ucak S, Ekmekci TR, Basat O, Koslu A, Altuntas Y. Comparison of various insulin sensitivity indices in psoriatic patients and their relationship with type of psoriasis. J Eur Acad Dermatol Venereol 2006;20:517-22.
[Google Scholar]

Fulltext Views
1,655

PDF downloads
2,060
Show Sections