Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Letter to the Editor
2014:80:4;367-369
doi: 10.4103/0378-6323.136952
PMID: 25035376

Primary mucinous carcinoma of skin with psammoma bodies

Debarshi Saha, Urmila N Khadilkar, Radha R Pai, Ashwani Kumar
 Department of Pathology, Kasturba Medical College (Manipal University), Mangalore, Karnataka, India

Correspondence Address:
Debarshi Saha
Department of Pathology, Kasturba Medical College, Light House Hill Road, Mangalore - 575 001, Karnataka
India
How to cite this article:
Saha D, Khadilkar UN, Pai RR, Kumar A. Primary mucinous carcinoma of skin with psammoma bodies. Indian J Dermatol Venereol Leprol 2014;80:367-369
Copyright: (C)2014 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

Primary mucinous carcinoma of skin (PMCS), a rare malignant tumor of the sweat glands or their germinal structures was first described by Lennox et al., in 1952. [1] This tumor is usually of eccrine origin; [2] less commonly, it is of apocrine derivation. [3] We report the presence of psammoma bodies in PMCS, which is an exceptional phenomenon.

Our patient, a 55-year-old male, had a small (1.2 cm diameter) skin colored cystic nodule on his left cheek, below the lower eyelid, which had been present for 6 months. The lesion was excised with a margin of 1 cm.

Microscopy showed an atrophic epidermis overlying a dermal tumor with prominent wide lakes of mucin separated by thin fibrous septae. Floating in these lakes, were cribriform cohesive nests composed mainly of dark cuboidal cells with slight pleomorphism and some pale cells towards the centre. Within these nests, there were numerous tubules containing mucin [Figure - 1]b. Concentric lamellations, identified as psammoma bodies, were found both freely floating, as well as in the nests [Figure - 1]a and [Figure - 3]f. Occasional partially calcified hyaline globules were seen within glandular lumina [Figure - 2]e.

Figure 1: (a) Numerous psammoma bodies in the tumor cell nests as well as in the mucin (H and E, ×100) (b) Dark cuboidal tumor cell nests floating in mucin (H and E, ×100) (c) Mucin stains with Alcian blue at pH 2.5 (×100)
Figure 2: (a) P63 - negative in the tumor cells (×100). (b) Smooth muscle actin - positive in the spindled cells lining the fibrous septae in the tumor (×100). (c) Estrogen receptor - strongly positive in the tumor cells (×100). (d) Progesterone receptor - strongly positive in the tumor cells (×100). (e) Partially calcified hyaline globule in a glandular lumen (H and E, ×100)
Figure 3: (a) Cytokeratin 7 (CK7) - strongly positive in the tumor cells (×100). (b) CK20 – negative in tumor cells (×100) (c) CK20 -positive in control slide of colonic adenocarcinoma (×100). (d) Thyroid transcription factor-1 (TTF-1) - negative in tumor cells (×100). (e) TTF- 1 - positive in control slide of thyroid follicular cells (×100). (f) Psammoma bodies inside glandular lumina in the tumor (marked by green arrows, H and E, ×100)

The mucin stained positively for periodic acid-Schiff and Alcian blue at pH 2.5 [Figure - 1]c suggesting non-sulfated sialomucin. Since metastatic mucinous carcinoma of the breast and other internal organs are included in the differential diagnosis, clinical and ultrasonologic breast examination, digital rectal examination of the prostate, abdominal ultrasound, colonoscopy, upper GI endoscopy and CT scan of the chest and neck were done, all of which were within normal limits. Follow-up 1½ years later showed a faint flushed scar and no evidence of any neoplasm.

While p63 was negative [Figure - 2]a, smooth muscle actin (SMA) was positive in the few flattened cells lining the fibrous septae [Figure - 2]b. The tumor cells stained strongly positive for estrogen [Figure - 2]c and progesterone [Figure - 2]d receptors (ER, PR). The tumor cells, although cytokeratin 7 (CK7) positive, were CK20 and thyroid transcription factor-1 negative [Figure - 3]a-e. Thus, a diagnosis of PMCS was made.

PMCS favors males (58.8%) over females (41%) and most commonly occurs in the head and neck region, with the eyelid being the preferred site (41%). [2] It usually presents as a painless, solitary, flesh colored to erythematous nodule of size varying from 3-4 mm to 20 cm, [1] usually not greater than 7-8 cm. [3] The histopathological appearance has been classically described as flotsam of dark tumor cells containing gland formations on faintly staining vast mucin lakes, partitioned by thin fibrous septae. [1],[2],[3] The histogenesis of this tumor has been suggested as a progression of abnormal eccrine or apocrine ducts, analogous to that of mucinous breast carcinoma. [4]

The differential diagnoses include mucinous carcinomas that metastasize to the skin arising from the breast, GI tract, respiratory tract, salivary and lacrimal glands, urinary tract, prostate and paranasal sinuses. [2] Of these, mucinous breast carcinomas stain positively for CK7 and may metastasize to the skin of the chest, breast and axilla, but rarely, the face. [1] The tumor cells of PMCS stain positively for low molecular weight cytokeratins (CK7, CAM 5.2), CEA, epithelial membrane antigen and S100 (inconstant). [3] The nuclei stain positively for ER and variably, PR, indicating its close histogenesis with that of mucinous breast carcinoma [3] and in our case, both were positive. However, an in situ component of the tumor may stain for CK5/6, p63, calponin and SMA on the myoepithelial cells and this may attest to the tumor being primary and not metastatic mucinous breast carcinoma. [5] In our case, p63 was negative but SMA was positive, indicating the presence of myoepithelial cells, thus, signifying a primary tumor rather than a metastatic one. GI carcinomas show CK20 positivity while PMCS is CK20 negative, but CK7 positive. [1],[3] GI carcinomas produce non-sulfated, neutral or sulfated mucins and not sialomucin, which is found in PMCS. [2] Metastatic colonic carcinomas may show dirty necrosis. [3]

Psammoma body formation is an active process where collagen fibers and membrane bound vesicles are laid down in concentric circles inside the papillary cores which are subsequently calcified. [6] Interestingly, papillary formations were absent in the present case. However, hyaline globules, which are the putative precursors of psammoma bodies [6] were present inside a few of the glandular lumina.

We found only one previous report of psammoma bodies in PMCS. [7]

References
1.
Lennox B, Pearse AGE, Richards HGH. Mucin secreting tumors of the skin. With special reference to the so-called mixed salivary tumor of the skin and its relation to hidradenoma. Journal of Pathology and Bacteriology. 1952; 64:865-880.
[Google Scholar]
2.
Martinez SR, Young SE. Primary mucinous carcinoma of skin: A review. Internet J Oncol 2005;2 (2) DOI: 10.5580/13e7.
[Google Scholar]
3.
Calonje E, Brenn T, Lazar A, McKee PH. McKee's Pathology of the Skin with Clinical Correlation. 4 th ed., Vol. 2. Philadelphia: Elsevier Saunders; 2012. p.1566-8.
th ed., Vol. 2. Philadelphia: Elsevier Saunders; 2012. p.1566-8.'>[Google Scholar]
4.
Kazakov DV, Suster S, LeBoit PE, Calonje E, Bisceglia M, Kutzner H, et al. Mucinous carcinoma of the skin, primary, and secondary: A clinicopathologic study of 63 cases with emphasis on the morphologic spectrum of primary cutaneous forms: Homologies with mucinous lesions in the breast. Am J Surg Pathol 2005;29:764-82.
[Google Scholar]
5.
Qureshi HS, Salama ME, Chitale D, Bansal I, Ma CK, Raju U, et al. Primary cutaneous mucinous carcinoma: Presence of myoepithelial cells as a clue to the cutaneous origin. Am J Dermatopathol 2004;26:353-8.
[Google Scholar]
6.
Das DK. Psammoma body: A product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor? Diagn Cytopathol 2009;37:534-41.
[Google Scholar]
7.
Kalebi A, Hale M. Primary mucinous carcinoma of the skin: Usefulness of p63 in excluding metastasis and first report of psammoma bodies. Am J Dermatopathol 2008;30:510.
[Google Scholar]

Fulltext Views
3,001

PDF downloads
1,406
Show Sections