Recurrent ulcers in the flexures of a 48-year-old woman
2 Department of Pathology, Care Institute of Medical Sciences, Hyderabad, Telangana, India
Laxmi Chandravathi Penmetcha
Department of Dermatology, Care Institute of Medical Sciences, Road No. 10, Banjara Hills, Hyderabad - 500 034, Telangana
|How to cite this article:
Penmetcha LC, Awake P, Fonseca A. Recurrent ulcers in the flexures of a 48-year-old woman. Indian J Dermatol Venereol Leprol 2016;82:740-743
A 48-year-old woman presented with a 4-year history of recurrent painful erythematous ulcerated lesions in with purulent secretion along with fibrosis and adhesions in her right axilla [Figure - 1]a and multiple severe ulcers in both groins disabling the mobility of limbs [Figure - 1]b. The remainder of the mucocutaneous examination including hair, nails, teeth and mucosae was normal.
|Figure 1: (a) Erythematous ulcers with adhesions in the right axilla. (b) Multiple severe ulcers in both groins|
There were no costitutional symptoms. The patient had diabetes mellitus and hypertension. Systemic examination was normal. Serum biochemistry, lung function tests and, urine osmolality were all within normal limits. Bone marrow biopsy report showed no abnormality. Imaging studies were normal. A skin biopsy specimen was obtained from the lesions.
Histopathological examination revealed a nodular infiltrated lesion in dermis. The overlying epidermis was ulcerated and the dermis showed a lesion composed of ovoid cells with moderate amounts of eosinophilic cytoplasm and an indented reniform nucleus with an admixed cellular inflammatory infiltrate of neutrophils, eosinophils and mast cells [Figure - 2]a and [Figure - 2]b. On immunohistochemical study, the tumoral cells showed strong cytoplasmic positivity for CD1a and were negative for CD 68 [Figure - 3].
|Figure 2: (a) Nodular infiltrated lesion in dermis with ulcerated overlying epidermis (H and E, ×10). (b) Ovoid cells with moderate amounts of eosinophilic cytoplasm and an indented reniform nucleus with an admixed cellular inflammatory infiltrate of neutrophils, eosinophils and mast cells (H and E, ×400)|
|Figure 3: Immunohistochemical staining is positive for CD1a (immunostain CD1a, ×100)|
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