Response from the author
A-242, Surya Nagar, Ghaziabad - 201011
|How to cite this article:
Gandhi V. Response from the author . Indian J Dermatol Venereol Leprol 2003;69:313-314
I thank Dr. S. Panda for taking interest in our article and sharing the results of his own study (yet unpublished). It is true that the report of Kano et al, who treated 3 patients with a low dose of pentoxifylline (300 mg daily), stimulated us to carry out a trial in a larger patient group to assess whether an economically viable and safe drug like pentoxifylline (Pf) would provide a therapeutic option for Schamberg′s disease (SD) which, till date, remains a condition that is easy to diagnose but difficult to treat. Our preliminary results were gratifying. Now responding to Dr Panda′s comments and queries:
1. Dr. Panda′s statement that the topical steroids are the traditional therapeutic modality in this disorder′ is far from true. Topical steroids may be of some help, particularly in itching purpura, but prolonged use may only exacerbate the problem.
2. Dr. Panda agrees that capillary stasis and gravity are contributory factors in the pathogenesis of SD., So there has been no paradigm shift as proposed by Dr. Panda after the study of Kano et al. For astute clinicians, SD always was and remains a capillaritis treated not by taking refuge in the panacea of topical steroids (as proposed by
Dr. Panda). In fact, modalities like PUVA, azathioprine, griseofulvin and cyclosporin A have been successfully used in the recent past.
3. Regarding the methodology, it is clear from the title itself that we have conducted a preliminary therapeutic trial and not a case-control randomized study or a dose comparison study. So the question of using a placebo group does not arise. The purpose of conducting a pilot study is to test the efficacy of a drug in a limited number of patients and to stimulate the interest of other workers in the field. Indeed this is exactly what Panda et al have done. In fact, their own results (whatever vignettes are available from Dr. Panda′s correspondence as his study is yet to be published and so unavailable for detailed review) seem to echo our methodology and results and serve as an endorsement for the efficacy of Pf. Their treatment period is also 8 weeks but surprisingly they have concluded that a 2 month period was deemed inadequate. Indeed this aspect of Dr. Panda′s study disappoints me. He had the luxury of a large study group (n = 112), which was not the case with us. So what prevented him from conducting a proper dose ranging study with a placebo group instead of a comparative trial with a single dosage regimen of 1200 mg and comparing it with an outdated modality like topical steroids. Why did he limit his treatment period to 8 weeks instead of carrying on from where other preliminary trials (including ours) have ended and extended the period to 6 months. Then perhaps many of the queries he has raised would have been answered. I may further remind Dr Panda that till date our trial remains the largest published trial (n = 20) of Pf in SD. We will reserve our comments on his study for later when it is published.
4. The optimum dose of Pf in SD remains open to debate. SD is a capillaritis and not a true vasculitis. So blindly aping the conventional dose used in vasculitides (400 mg thrice daily) may not be wise. The classic example of D-penicillamine is fresh in our mind where conventionally a dose of 250 mg thrice daily was accepted in systemic sclerosis till a dose ranging study found a lower dose of 125 mg on alternate days to be equally effective. Who knows we may be in for another pleasant surprise in the case of Pf in SD. Our recommendation is to conduct a dose ranging placebo controlled trial. If Dr. Panda et al, with the luxury of a study population of 112 patients, had done so, they would have provided answers to all the queries that they are raising.
Kano Y, Hirayama K, Orihara M, Shiohara T. Successful treatment of Schamberg's disease with pentoxifylline. J Am Acad Dermatol 1997;36:827-30.[Google Scholar]
Dowd PM, Champion RH. Purpura. In: Champion RH, Burton JL, Burns DA, Breathnach SM, editors. Textbook of dermatology. 6th ed. Oxford: Blackwell; 1998. p. 2151.[Google Scholar]
Lahiri K, Malakar S, Panda S. Are Schamberg's disease and stasis dermatitis spectral manifestations of the same disease? Ind J Dermatol 1999;44:220-1.[Google Scholar]
Shelley WB, Swaminathan R, Shelley ED. Lichen aureus: A hemosiderin tattoo associated with perforator vein incompetence. J Am Acad Dermatol 1984;11:260.[Google Scholar]
Clements PJ, Furst DE, Wong WK, et al. High-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis. Arth Rheum 1999;42:1194-203.[Google Scholar]