Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Commentary
89 (
4
); 499-500
doi:
10.25259/IJDVL_569_2023
pmid:

Role of antioxidants in Psoriasis – a long road ahead?

Department of Dermatology and Venereology, Government Medical College, Kozhikode, India
Department of Dermatology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, India

Corresponding author: Dr. Neelakandhan Asokan, Dermatology and Venereology, Government Medical College, Kozhikode, India. asokann65@gmail.com

Licence
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

Much research has been done on the pathogenesis of psoriasis during the last few decades. This has led to the development of several new strategies for its treatment. Psoriasis, like many other skin diseases, is increasingly viewed as a manifestation of dysregulated immunity and inflammation. There are several players in the pathogenesis of psoriasis including genes, cells, such as lymphocytes, dendritic cells, mast cells, neutrophils and keratinocytes, cytokines, such as interferon alpha and gamma, interleukins 17, 22 and 23, tumour necrosis factor-alpha, innate immunity and autoantigens.1 Two other factors of current interest are oxidative stress and the altered expression of microRNAs by the keratinocytes.2,3

Cells use several methods to preserve intracellular levels of reactive oxygen species (ROS) and overall redox homoeostasis to avoid damage to DNA, proteins and lipids.2 Oxidative stress is a state of imbalance wherein reactive oxygen species overwhelm the intrinsic antioxidant mechanisms resulting in cellular damage. It is known to have a role in the pathogenesis of various diseases like hypertension, diabetes mellitus, heart disease, cancers and skin diseases like atopic dermatitis, seborrhoeic dermatitis, vitiligo, psoriasis, alopecia areata, lichen planus, acne and rosacea.2

Previous studies have demonstrated that the total oxidant capacity is high in psoriasis, whereas the total antioxidant capacity is low.4 The ischaemia-modified albumin (IMA) which is a marker of oxidative stress is also increased.5 Expression of micro-RNA (mi R146a and mi R203) is altered on lesional keratinocytes and peripheral blood.3 In this issue of the journal, Uzun et al. from Turkey report the results of their research concerning these processes. 6 They have concluded that the total antioxidant capacity is markedly decreased in patients with psoriasis. The decrease in the levels of ischaemia-modified albumin and increased expression of mi R203 noted in univariate analysis did not remain significant in multivariate analysis. Moreover, the finding of decreased ischaemia-modified albumin is not consistent with previous studies and is against the conventional pathogenetic model of the disease.

The possible effect of treatment on the variables and not measuring serum albumin which could affect ischaemia-modified albumin have been mentioned as limitations of the study by the authors. There could be a few more. For instance, it may not be possible to attribute an aetiologic role for the biochemical changes mentioned in this study. This is because it is difficult to ascertain if these preceded the onset of psoriasis. The sample size has been calculated based on the prevalence of psoriasis and not on any of the exposure or outcome variables of the study which would have been relevant here. Though the authors report the results of multivariate regression, it is not clear whether they considered confounding factors such as age, gender or obesity in the regression model.

Targeting oxidative stress has been an attractive strategy in the treatment of various skin diseases, including psoriasis. However, the available evidence is not sufficient to establish their efficacy.2 Based on this report, it may be worthwhile to continue research on the role of these and other possible pathogenetic factors, some of which have a fundamental bearing on the development of psoriasis. Such research may also lead to the development of newer treatment modalities for psoriasis in future.

Declaration of patient consent

Patient’s consent is not required as there are no patients in this study.

Financial support and sponsorship

Nil.

Conflict of interest

There is no conflict of interest.

References

  1. , , , , , . Scanning the Immunopathogenesis of Psoriasis. Int J Mol Sci. 2018;19:179.
    [Google Scholar]
  2. , , . Oxidative stress and antioxidant strategies in dermatology. Redox Rep. 2016;21:164-9.
    [Google Scholar]
  3. , , . Understanding psoriasis: Role of miRNAs. Biomed Rep. 2018;9:367-74.
    [Google Scholar]
  4. , , , , , , . The relationship between oxidative stress, smoking and the clinical severity of psoriasis. J Eur Acad Dermatol Venereol. 2013;27:e370-5.
    [Google Scholar]
  5. , , , , , . Assessment of ischaemia-modified albumin level in patients with psoriasis. Clin Exp Dermatol. 2012;37:610-4.
    [Google Scholar]
  6. , , , , . Total oxidant capacity, total antioxidant capacity, ischemic modified albumin, microRNA levels and their relationship with psoriasis area and severity index. Indian J Dermatol Venereol Leprol doi: 10.25259/IJDVL_111_2022
    [Google Scholar]

Fulltext Views
2,981

PDF downloads
2,588
View/Download PDF
Download Citations
BibTeX
RIS
Show Sections