Therapeutic efifect of doxepin in chronic idiopathic urticaria
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Ghose S, Haldar S. Therapeutic efifect of doxepin in chronic idiopathic urticaria. Indian J Dermatol Venereol Leprol 1990;56:218-220
AbstractAmong 56 recalcitrant cases of chronic idiopathic urticaria 28 subjects (Group A) selected at random, were, treated with doxepin 10 mg thrice daily and the rest ( Group B ) with pheniramine maleate 22.5mgthrice daily.B 3 weeks of therapy group.A and group B respectively showed complete remission in 28.6% and 10.7% cases, partial remission in 64.3% and 39.3% cases and no improvement in 7.1% and 50% cases. The difference in clinical improvement between the two groups was statistii significant (p0.001). One week after stopping the treatment among totally syrnptom - free patients, 37.5% in group A and 100% in-group B developed recurrence. Drowsiness was more common in-group B (60.7%) than in group A (35.7%) whereas dryness of the mouth was more frequent in group A (64.3%) than in group B (46.4%).