Topical methotrexate therapy in palmoplantar psoriasis
B C Ravi Kumar
Department of Skin & STD, Kasturba Medical College, Manipal-576 119, Karnataka
|How to cite this article:
Ravi Kumar B C, Kaur I, Kumar B. Topical methotrexate therapy in palmoplantar psoriasis. Indian J Dermatol Venereol Leprol 1999;65:270-272
Palmoplantar psoriasis (PPP) is a disabling and disfiguring condition frequently resistant to conventional topical therapies. Sixteen patients of palmar and/or plantar psoriasis were treated with 1% methotrexate gel using propylene glycol as vehicle twice daily for 8 weeks. Patients were assessed for severity of erythema, scaling, induration and fissuring (ESIF) of the lesions weekly for one month and subsequently once every two weeks. Patients with more than 50% Improvement of the lesions were considered to have good improvement. Fifteen patients completed the study period. Eight out of ten (80%) patients with palmar psoriasis and 9 out of 14 (64%) patients with plantar psoriasis showed good improvement. The mean duration for >50% improvement was 40.3 days for palms and 52.9 days for soles. There were no side effects in any patient. Topical methotrexate, when administered in a suitable vehicle and applied for sufficient time is beneficial in PPP.