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Observation Letter
88 (
); 101-103

Coexistence of psoriasis and linear IgA disease: An uncommon presentation

Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India
Department Pathology, Armed Forces Medical College, Pune, Maharashtra, India
Corresponding author: Dr Shekhar Neema, Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Neema S, Bhatt S, Kashif AW, Radhakrishnan S. Co-existence of psoriasis and linear IgA disease: An uncommon presentation. Indian J Dermatol Venereol Leprol 2022;88:101-3.


Psoriasis is a common immune-mediated, autoinflammatory disorder occurring in genetically predisposed individuals. It is seen in 0.4–2.8% of Indian population. Linear IgA disease is a relatively rare dermatoses with an estimated incidence of 0.2–2.3 cases per million per year.1 It is characterized by the formation of tense vesicles or bullae, often in an annular pattern with blistering along the edge of the lesion – the so-called ‘string of pearl’ appearance. It is observed in two peaks of different age groups. The first peak usually occurs in six months to six years of age and is known as chronic bullous disease of childhood, while the second peak occurs at around 60 years of age. The coexistence of autoimmune bullous diseases with psoriasis is not uncommon. Most of the reported cases show association with bullous pemphigoid; however, the coexistence of psoriasis with pemphigus vulgaris, pemphigus foliaceous, linear IgA disease, cicatricial pemphigoid, epidermolysis bullosa acquisita and anti p200 pemphigoid is also known.2 The development of psoriasis in a patient of linear IgA disease is rare in literature and presents a unique therapeutic challenge.

A 65-year-old man presented with multiple tense vesicles and bullae associated with severe itching. A few vesicles on the trunk had an annular pattern [Figure 1a]. No mucosal involvement was noted. No signs of any other skin disease were noted. Skin biopsy from the lesions revealed subepidermal, non-acantholytic blisters containing neutrophils, eosinophils and fibrin [Figure 1b]. Direct immunofluorescence showed linear deposition of IgA at dermo-epidermal junction [Figure 1c]. Based on clinical and histopathological findings, a diagnosis of linear IgA disease was made and patient was managed with intravenous methylprednisolone pulse 1 g daily for three days and tablet dapsone 100 mg once a day to which he responded well within one month. After two months, he presented with 40% body surface area involvement with multiple erythematous scaly plaques that showed positive grattage test as well as Auspitz sign and psoriasis assessment and severity index score of 28.6 [Figure 2a]. Dermoscopy [Figure 2b] and histopathology were consistent with psoriasis. In next one week, he developed tense vesicles on areas affected with psoriasis [Figure 3a]. Dermoscopy showed features of psoriasis in the form of regular dotted vessels and well circumscribed yellow lacunae suggestive of bullae [Figure 3b]. Histopathology showed parakeratosis, regular elongation of rete ridges and sub-epidermal blister [Figure 3c]. His condition was diagnosed as linear IgA disease with chronic plaque psoriasis. He was treated with methotrexate 15 mg per week and dapsone 100 mg once a day was continued. There was significant improvement in psoriasis and linear IgA disease at four weeks.

Figure 1:: (a) Tense vesicles and bullae can be seen on both lower legs. Few vesicles have annular distribution (medial aspect of right knee). (b) Histopathology of LAD lesion shows sub-epidermal blister and neutrophils, eosinophils and fibrin in blister cavity (H & E, 40×) (c) Direct immunofluorescence shows IgA deposition on basement membrane (DIF, 40×)
Figure 2:: (a) Multiple well defined, erythematous scaly plaques over trunk (b) Dermoscopy of psoriatic plaque shows presence of regular dotted vessels (blue circle) and white scale (Dermlite DL4, polarized, ×10)
Figure 3:: (a) Tense vesiculo-bullous eruptions over psoriatic plaque (b) Dermscopy of co-existence of psoriasis and LAD shows presence of regular dotted vessels (blue circle), white scales (orange arrow) and yellow lacunae (blue arrow) (Dermlite DL4, polarized, ×10) (c)Histopathology of co-existent lesion shows parakeratosis, regular acanthosis and subepidermal blister (H& E, 100×)

The coexistence of autoimmune bullous diseases and psoriasis vulgaris was first described by Bloom in the year 1929. In the largest case series of psoriasis and autoimmune bullous diseases coexistence of 145 cases, linear IgA disease – psoriasis coexistence contributed to 2.1% of all cases. The most common autoimmune bullous diseases seen with psoriasis were bullous pemphigoid seen in 78 (53.8%) cases and anti-laminin γ1 pemphigoid in 40 (27.6%) cases.3 Patient with psoriasis developing autoimmune bullous diseases is commoner as compared to autoimmune bullous diseases developing psoriasis. The underlying pathomechanism maybe due to the epitope spreading. Chronic injury to the basement membrane in psoriasis along with the trafficking of lymphocytes and antigen-presenting cells, exposes basement membrane components to autoreactive lymphocytes that may predispose to autoimmune disease. The similar mechanism has been implicated in coexistence of lichen planus with bullous pemphigoid, Stevens-Johnson syndrome and secondary onset cicatricial pemphigoid.4 The sera of some of the psoriasis patients contains circulating IgA immune complex that may be responsible for the development of linear IgA disease.5 In our patient, psoriasis developed after linear IgA disease. The possible mechanism may be similar to koebnerization. The damage to the keratinocytes due to the disease process and intense itching can lead to the release of cathelicidin (LL-37), which acts as autoantigen, binds to the toll-like receptor 7 (TLR 7) in plasmacytoid dendritic cells. Type 1 IFN released by stimulated plasmacytoid dendritic cells promotes conversion of naive T cells to Th1 and Th17 cells; thereby causing psoriasis.

Choosing treatment in these patients is challenging. Steroid withdrawal is a known precipitating factor for erythrodermic and pustular psoriasis. We managed our patient with combination of methotrexate and dapsone with significant improvement in symptoms after four weeks. Methotrexate inhibits dihydrofolate reductase and dapsone inhibits dihydropteroate synthetase, components of folate pathway and their concomitant use increases the risk of hematologic toxicity. Other alternative drugs which can be used for the management of psoriasis in this scenario can be apremilast, cyclosporine, tumour necrosis factor (TNF)-alpha inhibitor or IL-17 blockers. However, affordability was a concern and we continued this combination with close monitoring of patient with successful outcome. Once our patient is in remission for six months, we plan to stop dapsone and continue methotrexate for another three to six months before tapering.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.


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  3. , , , , , , et al. Coexistence of autoimmune bullous diseases (AIBDs) and psoriasis: A series of 145 cases. J Am Acad Dermatol. 2015;73:50-5.
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