Liver function and immunoglobulins in skin lichen palnus

Abstract

Fifty-two patients of skin lichen planus conforming to the clinical and histopathological description were subjected to the different liver function tests. Age and sex matched clinically normal equal number of persons were taken as controls to exclude liver disorders.] Seven (13.46%) of the patients used to consume mild to moderate amount of alcohol. Nine (17.30%) cases gave the history of jaundice in the past and all of them had hepatomegaly. Otherwise hepatomegaly was observed in 37 (71.15%) cases. None of the healthy controls had hepatomegaly. Aspartase iminotransferase (AST) alanine aminotransferase (ALT) and alkaline phosphatase was raised in 11 (21.15%), 4 (7.69%) and 10 (19.23%) cases respectively. HBsAg was not detected in any of the 52 patients.The most contradictory finding was the revelation of raised immunoglo bulin of G, A or M either singly or in different combinations. IgG and IgA were raised in 32 (61.53%) cases while IgM in 26 (50.0%).